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Paper | Regular issue | Vol 45, No. 11, 1997, pp.2217-2221
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7956
Suzuki Couplings with Phthalimidines - An Efficient Route to Staurosporinone Analogs

Kenneth C. Rupert, John H. Dodd, and James R. Henry*

*The R. W. Johnson Pharmaceutical Research Institute, Route 202, P.O. Box 300, Raritan, NJ 08869-0602, U.S.A


Staurosporinone analogs have been prepared by an efficient process. The key step is a palladium mediated Suzuki coupling between a bromophthalimidine and an aromatic boronic acid.