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Paper | Regular issue | Vol 48, No. 1, 1998, pp.31-40
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7959
Oxazolo[4,5-g]-β-carbolines and Pyrazino[2,3-g]-β-carbolines. Synthesis of Modulators of the GABAA/Chloride Channel Complex

Preben H. Olesen,* Dieter Seidelmann, and John Bondo Hansen

*Medicinal Chemistry Research, Health Care Chemistry, Health Care Discovery & Development, Novo Nordisk A/S, Novo Nordisk Park DK 2760 Maaloev, Denmark


The synthesis of oxazolo[4,5-g]-β-carbolines and pyrazino[2,3-g]-β-carbolines starting from 6-hydroxy-β-carbolines was investigated in order to prepare new ligands for the benzodiazepine site of the GABAA/chloride channel complex.