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■ Synthesis of a New δ-Lactone Bridged Apovincamine Derivative

Gábor Nárai, Pál Sohár, Antal Csámpai, and Béla Zsadon*

*Institute of Chemistry, Eötvös Loránd University Budapest, H-1518 Budapest 112, P.O.Box 32, Hungary

Abstract

Starting from (+)-17,18-dehydroapovincamine, a new δ-lactone bridged apovincamine derivative (6) was synthesized in two steps involving oxidative hydroboration followed by catalytic hydrogenation. The structure elucidation of this compund, the intermediate and the by-products was performed by IR, ¹H- and ¹³C-NMR methods including DNOE measurements.