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Note | Regular issue | Vol 48, No. 1, 1998, pp.151-154
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7983
Synthesis of a New δ-Lactone Bridged Apovincamine Derivative

Gábor Nárai, Pál Sohár, Antal Csámpai, and Béla Zsadon*

*Institute of Chemistry, Eötvös Loránd University Budapest, H-1518 Budapest 112, P.O.Box 32, Hungary

Abstract

Starting from (+)-17,18-dehydroapovincamine, a new δ-lactone bridged apovincamine derivative (6) was synthesized in two steps involving oxidative hydroboration followed by catalytic hydrogenation. The structure elucidation of this compund, the intermediate and the by-products was performed by IR, 1H- and 13C-NMR methods including DNOE measurements.