Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Note | Regular issue | Vol 48, No. 1, 1998, pp.151-154
Published online, 1st January, 1970
DOI: 10.3987/COM-97-7983
■ Synthesis of a New δ-Lactone Bridged Apovincamine Derivative

Gábor Nárai, Pál Sohár, Antal Csámpai, and Béla Zsadon*

*Institute of Chemistry, Eötvös Loránd University Budapest, H-1518 Budapest 112, P.O.Box 32, Hungary

Abstract

Starting from (+)-17,18-dehydroapovincamine, a new δ-lactone bridged apovincamine derivative (6) was synthesized in two steps involving oxidative hydroboration followed by catalytic hydrogenation. The structure elucidation of this compund, the intermediate and the by-products was performed by IR, 1H- and 13C-NMR methods including DNOE measurements.