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Note | Regular issue | Vol 48, No. 1, 1998, pp.175-180
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8002
■ Saturated Heterocycles, Part 257. Preparation and Structure of Partially Saturated Isoindolo[1,2-b]- and -[2,1-a]quinazolinones

Pál Sohár, Géza Stájer, Angela E. Szabó, József Szúnyog, and Gábor Bernáth*

*Institute of Pharmaceutical Chemistry, Albert Szent-Györgyi Medical University, POB 121, H-6701 Szeged, Eötvös u. 6, Hungary

Abstract

Through the reactions of 2-carboxybenzaldehyde (1) with cis- or trans-2-amino-1-cyclohexylmethylamine (2a,b) or cis- or trans-2-amino-4-cyclohexenyl-1-methylamine (2c,d), the partially saturated isomeric isoindolo[1,2-b]- (3, 4, 6-8) and -[2,1-a]quinazolinones (5) were obtained. After separation, the structures of products (3-8) were established by NMR methods, including 2D-HSC DNOE and DEPT measurements. From the cis 2a, two linearly C/D cis-fused and one angularly C/D trans-fused tetracycles were formed.