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Paper | Regular issue | Vol 48, No. 1, 1998, pp.71-78
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8003
Synthesis of 4-Amino-3-quinolinesulfonic Acids and 4-Aminoquinolines

Leszek Skrzypek

*Department of Organic Chemistry, The Medical University of Silesia, Jagiellonska Str. 4, 41-200 Sosnowiec, Poland


The hydrolysis of 4-chloro-3-quinolinesulfonyl chloride (1) gives 4-chloro-3-quinolinesulfonic acid (2) or 1,4-dihydro-4-oxo-3-quinolinesulfonic acid (3). Compound (2) reacts with primary and secondary aliphatic or primary aromatic amines to give 4-amino-3-quinolinesulfonic acid (4). Desulfonation of quinolinesulfonic acids (2,3,4) yields 4(1H)-quinolinone or 4-aminoquinolines (5).