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Paper | Regular issue | Vol 48, No. 1, 1998, pp.95-102
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8010
A Convenient Synthetic Method for Fluorine-containing Benzo[h]quinolines from 2,4-Bis(trifluoroacetyl)-1-naphthylamine and Ketones

Etsuji Okada,* Norikado Tsukushi, Ting-Kai Huang, Hiroshi Tone, Nobuhiro Gotoh, Hiroshi Takeuchi, and Masaru Hojo

*Department of Chemical Science andd Engineerring, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

2,4-Bis(trifluoroacetyl)-1-naphthylamine (1) reacted easily with various ketones in the presence of aqueous ammonia or triethylamine to afford 6-trifluoroacetyl-4-trifluoromethylbenzo[h]quinolines (2) in moderate to excellent yields.