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Paper | Regular issue | Vol 48, No. 1, 1998, pp.103-112
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8018
Synthesis of Indole-fused 4-Pyridone-3-carboxylic Acids

Ho Joon Song, Min Yi Kim, Soon Bang Kang, Bong Young Chung, and Youseung Kim*

*Biochemicals Reserach Center, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 131-650, Korea


Some indole-fused tri- and tetracyclic 4-oxopyridine-3-carboxylic acids, quinolone-type derivatives, (3), (4) and (5) have been prepared. The synthesis is characterized by the construction of the pyridone ring through the intramolecular nucleophilic displacement cyclization at the 2-position of 3-substituted 1-methoxyindole accompanied with demethoxylation.