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Note | Regular issue | Vol 51, No. 1, 1999, pp.131-135
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8051
Ring Contraction of 3-Carboxamide or 3-Carboxylate of 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide and Analogous 1(2H)-Isoquinolinone-3-carboxylate

Ali Khalaj* and Neda Adibpour

*Department of Medicinal Chemistry, College of Pharmacy, Tehran Medical Sciences University, P.O.Box 14155-6451, Tehran, Iran

Abstract

A novel ring transformation of 3-carboxylate or 3-carboxamide of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide and analogous 1(2H)-iso-quinolinone-3-carboxylate to the 5-membered rings upon the reaction with carbonyl compounds in the presence of primary or secondary amines is described.