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Note | Regular issue | Vol 48, No. 4, 1998, pp.755-767
Published online, 1st January, 1970
DOI: 10.3987/COM-97-8083
Reaction of Proflavine Derivatives with Formaldehyde: Access to Mono- and Bis-(3,4-dihydro[1,3]oxazino)acridines of Pharmacological Interest

Noémie Fixler, Martine Demeunynck,* Alain Duflos, and Jean Lhomme*

*Ledss/UMR 5616, Université Joseph Fourier, 38041 Grenoble cédex 9, France

Abstract

Proflavine derivatives react with formaldehyde in acidic media to give 3,4-dihydro[1,3]oxazino condensed compounds. Depending on the nature of the solvents and the substituents attached to the exocyclic nitrogens, mono and bis reaction can occur.