Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 47, No. 2, 1998, pp.671-674
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)102
A New Synthetic Approach to a Fungal β-Lactone Based on the Asymmetric [2,3]-Wittig Rearrangement

Katsuhiko Tomooka, Takahiro Takeda, Au Wing Kuen, and Takeshi Nakai*

*Department of Chemical Technology, Faculty of Engineering, Tokyo Institute of Technology, Meguro-ku, Tokyo 152, Japan

Abstract

An asymmetric synthesis of the chiral β-lactone precursor of the HMG-CoA synthase, inhibitor L-659,699, is described, which involves as the key step an asymmetric [2,3]-Wittig rearrangement to control the stereogenic centers at the ring carbons (C2’ and C3’).