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Paper | Special issue | Vol 47, No. 2, 1998, pp.965-975
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)108
MCR 6: Chiral 2,6-Piperazinediones via Ugi Reactions with α-Amino Acids, Carbonyl Compounds, Isocyanides and Alcohols

Ivar Ugi,* Werner Hörl, Cordelia Hanusch-Kompa, Thomas Schmid, and Eberhardt Herdtweck

*Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany


A simple one-pot reaction based on the well known Ugi reaction for the generation of 2,6-piperazindiones is described, involving the multicomponent reaction of α-amino acids, carbonylcompounds, isocyanides and alcohols.