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Paper | Special issue | Vol 47, No. 2, 1998, pp.717-724
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)43
Photolysis of 13C-Methylcobalamin. Direct Detection of Generated Formaldehyde by Using 13C-Labeling

Kazuhiko Takatori, Yoshifumi Nakajima, Miyako Hirose, and Masahiro Kajiwara*

*Department of Medicinal Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

Photolysis of methylcobalamin was followed by UV, CD and 1H-NMR spectroscopic methods. The direct detection of formaldehyde as a photolysis product was achieved by 13C-NMR using 13C-methylcobalamin, prepared from vitamin B12 and 13C-methyl iodide, as a substrate.