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Communication | Special issue | Vol 47, No. 1, 1998, pp.157-161
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)59
Total Syntheses of (-)-Polyoxin J and (-)-Polyoxin L

Hiroyuki Akita,* Kimio Uchida, and Keisuke Kato

*School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

A convenient synthesis of the N-protected L-carbamoylpolyoxamic acid derivative (7) from 4-O-tert-butyldiphenylsilyl-2,3-isopropylidene-L-threose (8) using vinylmagnesium bromide and its application to the total syntheses of the peptidyl nucleoside antibiotics, polyoxins J (1) and L (2), are described.