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Communication | Special issue | Vol 47, No. 1, 1998, pp.171-175
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)73
Total Synthesis of NPTX-643, a Neurotoxin of the Madagascar Spider (Nephilengys borbonica ) Having a Novel Acylpolyamine Structure

Masaaki Miyashita,* Takanori Kanemura, Masayuki Matsushita, Susumi Hatakeyama, Yasuhiro Itagaki, Terumi Nakajima, Masahiro Miyazawa, and Hiroshi Irie

*Division of Chemistry, Graduate Sachool of Sceince, Hokkaido University, Sapporo 060-0810, Japan

Abstract

The first total synthesis of NPTX-643, a neurotoxin of the Madagascar spider (Nephilengys borbonica) having a unique cadaverine - nor-putreanine - putreanine acylpolyamine chain, has been achieved by using three key azide intermediates.