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Note | Special issue | Vol 47, No. 2, 1998, pp.1017-1022
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S(N)79
Alkyl 2-[2,2-Disubstituted Ethenyl]amino-3-dimethylaminopropenoates in the Synthesis of Heterocyclic System. An Alternative Method for Preparation of 3-Amino-4H-pyrido[1,2-a]pyrimidin-4-ones

Lovro Selic, Sonja Strah, Renata Toplak, and Branko Stanovnik*

*Faculty of Chemistry and Chemical Technology, University of Ljubljana, Askerceva 5, P.O. Box 537, SLO-1000 Ljubljana, Slovenia

Abstract

Substituted 3-amino-4H-pyrido[1,2-a]pyrimidin-4-ones (6) were prepared by treatment of 2-aminopyridines (1) with alkyl 2-[2,2-disubstituted ethenyl]amino-3-dimethylaminopropenoates (2) in which 3-[2,2-disubstituted ethenyl]amino-4H-pyrido[1,2-a]pyrimidin-4-ones (3 - 5) were formed. The removal of the N-protecting group with hydrazine afforded compounds (6).