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Communication | Special issue | Vol 49, No. 1, 1998, pp.29-32
Published online, 1st January, 1970
DOI: 10.3987/COM-97-S2
MCR IX: A New and Easy Way for the Preparation of Piperazine-2-keto-3-carboxamides

Alexander v. Zychlinski and Ivar Ugi*

*Institut für Organische Chemie und Biochemie , Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany


Piperazine-2-keto-3-carboxamides (5) are formed by an one-pot U-4CR (Ugi four component reaction) between ethylenediamine (1), glyoxylic acid-hemiacetal (2), a carboxylic acid (3) and an isocyanide (4).