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Note | Regular issue | Vol 48, No. 7, 1998, pp.1471-1476
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8169
Kinetic Resolution of Aryl Glycidyl Ethers: A Practical Synthesis of Optically Pure β-BlockerS-Metoprolol

Mukund K. Gurjar,* Kashinath Sadalapure, Susanta Adhikari, Bugga V. N. B. S. Sarma, Arindam Talukdar, and Mukund S. Chorghade

*Organic Chemistry Division III, Indian Institute of Chemical Technology, Hyderabad 500 007, India

Abstract

Kinetic resolution of (±)-aryl glycidyl ethers using (R,R)-salen Co(III)OAc and water provided enantiomerically pure arylglycidyl ether and 1-arylglycerol derivatives with high enantiomeric excess. Application of this approach to (S)-metoprolol has been described.