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Note | Regular issue | Vol 48, No. 9, 1998, pp.1931-1934
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8253
Studies on the Metabolites of Penicillium vulpinum

Mitsuko Makino, Toshinari Endoh, Yoshio Ogawa, Kazuko Watanabe, and Yasuo Fujimoto*

*College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan

Abstract

Two new metabolites, 2-methoxymethyl-3-pentylphenol (1) and 3-butyl-7-hydroxyphthalide (2), were isolated from the culture broth of Penicillium vulpinum along with four knwon phenols, gentisyl alcohol (3), 2-methylhydroquinone (4), 3-hydroxybenzyl alcohol (5), 6-methylsalicyclic acid (6), and epoformin (7). The structures of new metabolites were determined by analyses of their MS and NMR spectra. It was found that the cytotoxic activity of the culture broth of P. vulpinum was mainly due to epoformin (7) and 2-methylhydroquinone (4).