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Note | Regular issue | Vol 48, No. 11, 1998, pp.2353-2360
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8260
14,15-Disubstituted Marcfortine A Derivatives

Byung H. Lee* and Michael F. Clothier

*Animal Health Discovery Research, Pharmacia & Upjohn, Inc., 7000 Portage Road, Kalamozoo, MI 49001-0199, U.S.A.


The novel 14,15-disubstituted marcfortine A derivatives (4 and 14) were synthesized starting with known derivatives (5 and 10). Assay of their anthelmintic activity disclosed some novel aspects of the structure-activity relationships for marcfortine A (1).