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Paper | Regular issue | Vol 48, No. 10, 1998, pp.2103-2109
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8268
Trifluoroacetylation of Methylpyridines and Other Methylazines: A Convenient Access to Trifluoroacetonylazines

Masami Kawase,* Mutsumi Teshima, Setsuo Saito, and Satoru Tani

*Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japana

Abstract

Treatment of methyl substituted azines, such as pyridine, pyrimidine, quinoline, oxazole, benzoxazole, benzimidazole, and benzothiazole, with trifluoroacetic anhydride in the presence of pyridine at room temperature gave the corresponding trifluoroacetonyl substituted azines in good yields.