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Note | Regular issue | Vol 48, No. 11, 1998, pp.2361-2364
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8269
Studies on Urothion. Determination of the Absolute Configuration of the Dephospho Form B Derived from Urothion

Atsushi Sakurai,* Yuji Hashimoto, Nobuhiro Kuboyama, and Yasuaki Okumura

*Department of Chemisttry, Faculty of Science, Shizuoka University, Ohya, Shizuoka 422-8529


In order to determine the absolute configuration of urothion (4), the CD spectrum of the dephospho form B (3b) derived from 4 was compared with those of both enantiomers of the dephospho form B ((R)-3b and (S)-3b) which were prepared by asymmetric synthesis. R-Configuration was concluded for the secondary hydroxyl group on the side chain of 3b, as well as 4, which is the same configuration as that of molybdopterin (1). This supports the view that 4 might be a urinary metabolite of 1.