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Note | Regular issue | Vol 48, No. 10, 1998, pp.2163-2172
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8280
Synthesis and Antiviral Evaluation of 3-Hydroxymethylpyrimido[1,6-c][1,3]oxazepine Derivatives

Ling-Yih Hsu,* Ya-Fun Kang, and John C. Drach

*School of Pharmacy, National Defense Medical Center, P.O. Box 90048-508, Neihu, Taipei, Taiwan, R.O.C.

Abstract

A number of pyrimido[1,6-c][1,3]oxazepin derivatives, the anti glycosidic constrained acyclic analogs of uridine and cytidine have been prepared. Compounds synthesized were evaluated for activity against herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV). All of these compounds were inactive.