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Communication | Regular issue | Vol 48, No. 10, 1998, pp.1989-1992
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8284
Synthesis of Benzo[c]phenanthridine Alkaloids, Chelerythrine and Nitidine, Using a Novel Palladium-Phosphine Combination System - Pd(OAc)2, DPPP, and Bu3P -

Takashi Harayama,* Toshihiko Akiyama, Yuichiro Nakano, and Kentaro Shibaike

*Faculty of Pharmaceutical Science, Okayama University, 1-1-1 Tsushima-naka, Okayama 700-8530, Japan


Total synthesis of chelerythrine (1) and nitidine (4) was accomplished via the aryl-aryl cyclization reaction using a novel Pd reagent prepared from Pd(OAc)2, DPPP, and Bu3P. The present method was very versatile for coupling reaction not only between aromatic triflate and arene but also between aromatic halide and arene.