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Paper | Regular issue | Vol 48, No. 11, 1998, pp.2279-2285
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8293
Synthesis of Praziquantel via N-Acyliminium Ion Cyclization of Amido Acetals through Several Synthetic Routes

Joong Hyup Kim, Yong Sup Lee, and Choong Sup Kim*

*Division of Applied Science, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Korea


Syntheses of praziquantel have been accomplished via an N-acyliminium ion by several routes including the tandem nucleophilic addition-cyclization sequence from amido acetal (8) or (10) and a stepwise cyclization of enamide (9) generated from the nucleophilic addition reaction of amido acetal (8) or (10).