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Note | Regular issue | Vol 48, No. 12, 1998, pp.2631-2635
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8300
Formation of Highly Substituted Pyrrole Derivatives: An Unexpected Domino Reaction

Claudia Wittland and Nikolaus Risch*

*Universität-GH Paderborn, Fachbereich für Chemie und Chemietechnik, Warburger Str. 100, D-33098 Paderborn, Germany


An unexpected multistep domino reaction for the preparation of highly substituted pyrrole derivatives is described. During this reaction, which uses a secondary benzylic amine (e.g. N-benzyl-(1-phenylethyl)amine) and benzaldehyde as starting materials, a methyl group is transformed into a quaternary sp2-carbon atom and three equivalents of benzaldehyde are reduced.