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Paper | Regular issue | Vol 48, No. 12, 1998, pp.2529-2534
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8307
Synthesis of Furo[3,2-b]pyridine Analogue of Efaroxan

Patrice Mayer,* Chantal Loubat, and Thierry Imbert

*Division of Medicinal Chemistry, Centre de Recherche Pierre Fabre, 17, avenue Jean Moulin, 81100 Castres, France

Abstract

2-(4,5-Dihydro-1H-imidazol-2-yl)-2-ethyl-2,3-dihydrofuro[3,2-b]pyridine was synthesized in eight steps starting from 3-hydroxy-2-methylpyridine. The key step was a cyclization of a 2-chloromethyl-3-butyroxypyridine derivative. The target molecule is an aza analogue of efaroxan, a potent and selective antagonist of α2-adrenoceptors.