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Note | Regular issue | Vol 51, No. 1, 1999, pp.137-140
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8308
A Convenient Synthesis of Polyfunctionally Substituted 2',2'-Bis(ethoxycarbonyl)methylene-5'-methoxycarbonyl(cyano)spiro[dihydroacridine-9(10H),4'-thiazolidines]

Juraj Bernát, Igor Chomca, Pavol Kristian,* Kalevi Pihlaja, Karel Douglas Klika, and Ján Imrich

*Department of Organic Chemistry, P. J. SafÁrik University, Moyzesova 11, SK-04167 Kosice, Slovakia

Abstract

2-(Acridin-9-ylthiocarbamoyl)malonic acid diethyl esters (2a-c) obtained via reaction of isothiocyanatoacridines (1a-c) with sodium diethyl malonate afforded with methyl bromoacetate (bromoacetonitrile) non-isolable S-alkylated intermediates (3a-f), which cyclized in alkaline medium to 2’,2’-bis(ethoxycarbonyl)methylene-5’-methoxycarbonyl(cyano)spiro[dihydroacridine-9(10H),4’-thiazolidines] (4a-f).