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■ Syntheses of Fluorine-containing 1,2-Dihydropyrimidines and Pyridines from β,β-Bis(trifluoroacetyl)vinylamine, Ketones and Ammonia

Etsuji Okada,* Tatsuhiko Kinomura, and Yukio Higashiyama

*Department of Chemical Science andd Engineerring, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

β,β-Bis(trifluoroacetyl)vinylamine (1) reacted easily with various ketones in the presence of aqueous ammonia under mild conditions to give trifluoroacetylated 4-trifluoromethyl-1,2-dihydropyrimidines (4), α-trifluoromethylpyridines (5), and γ-trifluoromethylpyridines (6) in moderate yields.