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Note | Regular issue | Vol 48, No. 12, 1998, pp.2653-2659
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8327
Synthesis of 4-Silyl-substituted Methyl Nicotinates via Silylcupration of N-Acylpyridinium Salts

Cornelia E. Hösl and Klaus Th. Wanner*

*Institut für Pharmazie, Universität M&uuuml;nchen, Sophienstrasse 10, D-80333 München, Germany


A general synthetic method for the preparation of 4-silyl-substituted methyl nicotinates (5) is described. The reaction sequence includes a silylcupration of the N-acylated 3-methoxypyridinium salts (2) followed by oxidation of the resulting dihydropyridines (3) to give 5.