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Paper | Regular issue | Vol 51, No. 1, 1999, pp.67-76
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8338
Four New 4-Phenylcoumarins from Calophyllum dispar. Isolation and Hemisynthesis

David Guilet, Cécile Morel, Nathalie Noyer, Maryse Cornec, Denis Séraphin, Christian Wiart, A. Hamid A. Hadi, Thierry Sévenet, Pascal Richomme,* and Jean Bruneton

*U.F.R. des Sciences Medicales et Pharmaceutiques et Ingénierie de la Santé, SONAS, Université d'Angers, 16, Bd Daviers, F-49100 Angers, France


Four new 4-phenylcoumarins, disparinols A and B, isodisparinols A and B, having a 2-hydroxy-3-methylbut-3-enyl substituent were isolated from the bark of Calophyllum dispar (Clusiaceae). Their structures were established by means of spectroscopic studies and confirmed by hemisynthesis.