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Paper | Regular issue | Vol 51, No. 2, 1999, pp.281-293
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8378
Synthesis and Antitumor Activity of Javacarboline Derivatives

Hiroshi Yoshino, Kazuo Koike, and Tamotsu Nikaido*

*Department of Pharmacognosy, School of Pharmaceutical Sciences, Toho University, 2-2-1, Miyama, Funabashi, Chiba 274-8510, Japan

Abstract

Syntheses of 12H-pyrido[2,1-a]-β-carbolin-5-ium bromides (15-27) and 11H-pyrrolo[2,l-a]-β-carbo1ines (32-35), structurally related to the tetracyclic alkaloid javacarboline (1) have been achieved via 2 steps routes starting from the respective β-carbolines. Their synthetic compounds showed potent antitumor activities against P-388 murine leukemia cells and PC-6 human lung carcinoma cells.