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Paper | Regular issue | Vol 51, No. 3, 1999, pp.593-598
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8421
Chemoenzymatic Enantioselective Synthesis of (-)-Indolizidine 167B

Robert Chênevert,* Ghodsi Mohammadi Ziarani, and Mohammed Dasser

*Département de Chimie, Faculté des Sciences et de Génie, Université Laval, Cité Universitaire, Québec, G1K 7P4, Canada

Abstract

(5R, 9R)-(-)-Indolizidine 167 B was synthesized in 8 steps from N-benzyloxycarbonyl-cis-2(R)-acetoxyrnethy1-6(S)-hydroxymethy1piperidine (2) in an overall yield of 60%. This starting material was obtained from enzymatic desymmetrization of the corresponding meso diacetate (1).