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Paper | Regular issue | Vol 51, No. 6, 1999, pp.1275-1282
Published online, 1st January, 1970
DOI: 10.3987/COM-98-8471
Probing the TCDD Receptor: Synthesis of 5,6-Dihydro-6a,11,11b-triazabenzo[a]fluorene·PF6, a Potential Ligand

Joakim Tholander and Jan Bergman*

*Department of Organic Chemistry, Biosciences at Novum, Karolinska Institutet, S-141 57 Huddinge, Sweden


With the aim of investigating whether the ability of omeprazole (3) to activate the TCDD receptor is due to an internal cyclization process, 5,6-dihydro-6a,11,11b-triazabenzo[α]fluorene. PF6 (6) (X=PF6) has been designed and synthesized via a one-pot Mitsunobu reaction. An improved synthesis of the tosylate (10) of 2-(2-hydroxyethyl)pyridine has also been developed.