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Paper | Special issue | Vol 50, No. 2, 1999, pp.791-798
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S(H)73
Reaction of β-Cyanomethylene-β-enamino Diketones and -keto Esters with Hydrazines: Synthesis of Pyrazole and Pyridine Derivatives

Chiara B. Vicentini, Maurizio Manfrini, Manuela Mazzanti, and Augusto C. Veronese*

*Dipartimento di Scienze Farmaceutiche, Universita di Ferrara, via Fossato di Mortara 17, I-44100, Ferrara, Italy

Abstract

4-Acetyl-3-amino-5-oxo-3-hexenenitrile (1a) reacts with hydrazines to give pyrazolyl enaminonitriles (2) while 2-acetyl-3-amino-4-cyano-2-butenoic avid methyl ester (1b) reacts with hydrazines to give pyridine derivatives (6) or (7).