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Communication | Special issue | Vol 49, No. 1, 1998, pp.53-58
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S21
Synthesis and Cytotoxicity of Various Structural Types of Novel Cyclopropapyrroloindole(CPI) Derivatives

Yasumichi Fukuda,* Hirosuke Furuta, Yoshie Kusama, Hiroyuki Ebisu, Yasuo Oomori, and Shiro Terashima*

*Central Research Laboratories, Kyorin Pharmaceutical Co. Ltd., Mitarai, Nogi, Tochigi 329-0114, Japan

Abstract

The various structural types of novel cyclopropapyrroloindole (CPI) derivatives (7Å`10) were synthesized and their cytotoxicity was evaluated. Among these derivatives, 3-methoxycarbonylCPI(3-MCCPI) derivatives (8a,b) and cyclopropapyrrolocarbazole (CPC) derivative (10a) were found to exhibit comparable cytotoxicity to U-73,975 (adozelesin) (1).