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Communication | Special issue | Vol 49, No. 1, 1998, pp.63-66
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S29
Synthesis of Unnatural Enantiomer of Nectrisine and Its Biological Activity

Naoto Kogoshi, Akira Takatsuki, Yong Jip Kim, and Takeshi Kitahara*

*Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

Abstract

ent-Nectrisine (2), the unnatural enantiomer of nectrisine (1), a potent α-glucosidase inhibitor, was synthesized from D-glucose derivative. Biological assay showed that 2 had no significant bioactivity.