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Communication | Special issue | Vol 49, No. 1, 1998, pp.109-112
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S48
Synthesis and Evaluation of Enantiomerically Pure Azinomycin-Lexitropsin Hybrid Molecules with DNA-cleaving Activity

Kozo Shishido,* Shigenori Haruna, Hiromi Iitsuka, and Masayuki Shibuya*

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi 1, Tokushima 770-8505, Japan

Abstract

Several enantiomerically enriched azinomycin-lexitropsin hybrid molecules, (1a-c), (2a-c), (3a-c) and (12), were synthesized and their DNA-cleaving activities were evaluated. Of these, the compound (3c) with natural configuration was proved to exhibit the strongest activity.