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Communication | Special issue | Vol 49, No. 1, 1998, pp.43-47
Published online, 1st January, 1970
DOI: 10.3987/COM-98-S8
A Novel Synthesis of Thebaine from Codeine

Andrew Coop and Kenner C. Rice*

*Laboratory of Medicinal Chemistry, National Institute of Diabetes, Digestive and Kidney Diseases, Bldg 8, Rm B1-23, Bethesda, MD 20892-0815, U.S.A.

Abstract

Codeine was converted into thebaine through methylation of the enolate of codeinone.