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Paper | Regular issue | Vol 53, No. 1, 2000, pp.93-106
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8727
Synthesis and Conformational Analysis of Some New Pyrano[2,3-c]xanthen-7-one and Pyrano[3,2-b]xanthen-6-one Derivatives with Cytotoxic Activity

Konstantinos Ghirtis, Nicole Pouli, Panagiotis Marakos,* Alexios-Leandros Skaltsounis, Stephane Leonce, Daniel H. Caignard, and Ghanem Atassi

*Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Athens GR-15771, Greece

Abstract

The synthesis, conformational analysis and preliminary biological evaluation of some new pyrano[2,3-c]xanthen-7-ones and pyrano[3,2-b]xanthen-6-ones is described. Certain compounds possess interesting cytotoxic activity against murine leukemia L1210 cells.