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Paper | Regular issue | Vol 53, No. 1, 2000, pp.107-113
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8729
A Convenient Synthesis of 4-Trifluoromethylimidazol-1-ols

Yasuhiro Kamitori*

*Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Kobe 657-8501, Japan

Abstract

1,1,1-Trifluoroalkane-2,3-dione 3-oximes easily obtainable from aldehyde dialkylhydrazones were reacted with aldehydes in the presence of ammonium acetate followed by treatment with 1N HCl affording 4-trifluoromethylimidazol-1-ols in good yields.