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Note | Regular issue | Vol 53, No. 2, 2000, pp.419-422
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8755
Exchange Aminations in Conversions of Pyrimidinium Iodides to 2-Alkylaminonicotinic Acids

Gevorg G. Danagulyan,* Larisa G. Sahakyan, Alan R. Katritzky,* and Sergey N. Denisenko

*Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, U.S.A.

Abstract

1-Alkyl-2-(ethoxycarbonylmethyl)pyrimidinium iodides (1) are transformed into 2-alkylaminonicotinic acids (2) by reactions with aliphatic primary amines. Two alternative reaction paths are proposed, one of which involves exchange of the amine moieties.