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Note | Regular issue | Vol 53, No. 3, 2000, pp.709-715
Published online, 1st January, 1970
DOI: 10.3987/COM-99-8795
A Simple and Efficient Synthetic Method for Fluorine-containing 7H -[1]Benzothiopyrano[3,2-h ]quinolines

Etsuji Okada* and Norikado Tsukushi

*Department of Chemical Science and Engineering, Faculty of Engineering, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan

Abstract

Acid-catalyzed cyclization of 8-quinolyl aryl sulfides (2), prepared by aromatic nucleophilic nitrogen-sulfur exchange reaction of N,N-dimethyl-5,7-bis(trifluoroacetyl)-8-quinolylamine (1) with p-substituted benzenethiols, afforded the corresponding fluorine-containing 7H-[1]benzothiopyrano[3,2-h]quinolines (3-5) in excellent yields.