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Paper | Special issue | Vol 52, No. 3, 2000, pp.1163-1169
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S114
Synthesis of 3-Trifluoromethyl-3-aryldiazirines for Photoaffinity-labeling Probes and Their Labeling Ability

Chikanori Morita, Kimiko Hashimoto, Toshikatsu Okuno, and Haruhisa Shirahama*

*School of Science, Kwansei Gakuin University, Uegahara, Nishinomiya 662-8501, Japan

Abstract

Photoaffinity-labeling probes of aryldiazirine derivatives with three substituents (diazirine, nitro, and alkyl or alkoxy) on C1, C2, and C4 of the benzene nucleus were synthesized and their labeling abilities were tested. Among the synthetic compounds (4, 5, and 12), only 12 was appropriate for the photoaffinity probe.