Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Communication | Special issue | Vol 52, No. 1, 2000, pp.85-89
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S17
Palladium-catalyzed Ring Expansion of Hydroxy Methoxyallenylphthalans as a Novel Synthetic Method for Highly Substituted 4-Isochromanone Derivatives

Ill-Yun Jeong, Motoo Shiro, and Yoshimitsu Nagao*

*Faculty of Pharmaceutical Sciences, University of Tokushima, Sho-machi, Tokushima 770-8505, Japan

Abstract

The palladium(0)-catalyzed ring expansion reaction using hydroxy methoxyallenylphthalans (3) proceeded smoothly to give highly substituted 4-isochromanone derivatives (4), and treatment of commercially available phthalide (5) with lithium methoxyallene furnished two atom ring-expanded endo-benzoxepin-5-one (8).