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Paper | Special issue | Vol 52, No. 1, 2000, pp.313-324
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S26
Enantiospecific Total Syntheses of Nuphar Piperidine Alkaloids, (-)-Anhydronupharamine, (-)-Nupharamine, (-)-Nuphenine and (+)-3-Epinupharamine

Toshio Honda,* Fumihiro Ishikawa, and Shin-ichi Yamane

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

A concise enantiospecific synthesis of nuphar piperidine alkaloids was achieved by employing a regioselective carbon-carbon bond cleavage reaction of the cyclopentane derivative, having a γ-chloro carbonyl system, as a key reaction.