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Paper | Special issue | Vol 52, No. 1, 2000, pp.325-332
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S27
Phenanthridone Analogs of the Opiate Agonist U-47,700 in the trans-1,2-Diaminocyclohexane Benzamide Series

Shikai Zhao, Michael J. Totleben, Stephen A. Mizsak, Jeremiah P. Freeman, and Jacob Szmuszkovicz*

*Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN 46556, U.S.A.


The first rigid analog of the opioid trans-1,2-diaminocyclohexane benzamide template was prepared. This analog represented by compound (4b), in a phenanthridone analog of the mu agonist U-47,700 which, historically, was the forerunner of the kappa acetamide U-50,488.