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Communication | Special issue | Vol 52, No. 1, 2000, pp.133-136
Published online, 1st January, 1970
DOI: 10.3987/COM-99-S46
Novel Intramolecular Radical Ar-C Glycosylation-Lactonization Reaction in the Transformation of Capuramycin

Hitoshi Hotoda,* Makiko Daigo, Toshio Takatsu, Akiko Muramatsu, and Masakatsu Kaneko

*Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan


Radical deoxygenation of capuramycin derivative (2a,b) gave the unexpected lactone (3a,b) in moderate yield via a novel intramolecular radical Ar-C glycosylation-lactonization reaction. R-115381 and R-116022, thus obtained, showed weak antimicrobial activity against several Gram-positive bacteria.