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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Communication | Regular issue | Vol 2, No. 4, 1974, pp.461-466
Published online, 1st January, 1970■ A Novel Synthesis of Pyrimidines III. Cyclization of Alkyl N-Cyano-cyanoacetimidates
Published online, 1st January, 1970
DOI: 10.3987/R-1974-04-0461
■ A Novel Synthesis of Pyrimidines III. Cyclization of Alkyl N-Cyano-cyanoacetimidates
Tadamasa Hirayama,* Masahiro Kamada, Masataka Mimura, and Hideaki Tsurumi
*Central Research Laboratoeies, Daiichi Pharmaceutical Co., Ltd., 16-13, Kitakasai 1-chome, Edsogawa-ku, Tokyo 134, Japan
Abstract
Cyclization reaction of N-cyano-cyanoacetimidates (III) with hydrogen halides has been found to give a mixture of 4-alkoxy-6-amino-2-halogenopyrimidines (IV) and 4-alkoxy-2-amino-6-halogenopyrimidines (V). In the presence of a Lewis acid with hydrogen chloride, this reaction proceeded in one specific direction to give IV.
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