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Communication | Regular issue | Vol 3, No. 2, 1975, pp.163-166
Published online, 1st January, 1970
DOI: 10.3987/R-1975-02-0163
■ Photoreduction of Pyrimidine Nucleosides in the Presence of Sulfite Ion

Yoshikazu Kondo,* Fumihiko Yoshizaki, and Tsunematsu Takemoto

*Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan

Abstract

Irradiation of aqueous solutions of uridine and thymidine at pH 9 with 2537 Å-light in the presence of bisulfite revealed complete disappearance of the uv absorption. Hydrolysis followed by purification on silica gel column chromatography gave the corresponding dihydropyrimidine bases. In this reaction of thymidine 2-oxo-4-methoxy-5-methylhexahydropyrimidine was obtained in addition to dihydrothymine. Excess bisulfite was unaffected to the resulting dihydropyrimidine nucleus.