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Communication | Regular issue | Vol 4, No. 4, 1976, pp.713-718
Published online, 1st January, 1970
DOI: 10.3987/R-1976-04-0713
The Reactions of Ethyl 2-Quinolyl- and 2-Pyridylcyanoacetate

Takao Yamazaki,* Katsuhide Matoba, and Suguki Imoto

*Faculty of Pharmaceutical Sciences, ToyamaUniversity, Gofuku 3190, Toyama 930-8555, Japan

Abstract

Ethyl 2-quinolylcyanoacetate (II) was refluxed in trifluoroacetic acid to give a chemically very stable substance. The potassium salt (IVa) of II reacted with methyl iodide to afford selectively the C-methylated product, which was treated with alkali in ethanol to give methyl 2-quinolyl ketone (VIIa) in good yield. On the other hand, ethyl 2-cyano-2-(2-pyridyl)-propionate (XII) gave only 2-(2-pyridyl)propionitrile (XIV).